Class: Drug metabolism

Breaking news: schema.org has just implemented our proposal to define an additionalType property with the use of this service in mind!

pto:Drug_metabolism (rdf:type owl:Class)

URI http://www.productontology.org/id/Drug_metabolism
rdfs:subClassOf gr:ProductOrService, http://schema.org/Product
rdfs:label Drug metabolism (as a class or brand name of products of services)
Translation(s): استقلاب الدواء@ar; Metabolisme dels fàrmacs@ca; Metabolismo de fármacos@es; متابولیسم دارو@fa; Lääkeainemetabolia@fi; Métabolisme des médicaments@fr; Metabolismo de fármacos@gl; Xenobiotikumok metabolizmusa@hu; Metabolisme obat@id; Metabolismo dei farmaci@it;

rdfs:comment

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug or poison. These pathways are a form of biotransformation present in all major groups of organisms and are considered to be of ancient origin. These reactions often act to detoxify poisonous compounds (although in some cases the intermediates in xenobiotic metabolism can themselves cause toxic effects). The study of drug metabolism is the object of pharmacokinetics. Metabolism is one of the stages (see ADME) of the drug's transit through the body that involves the breakdown of the drug so that it can be excreted by the body. The metabolism of pharmaceutical drugs is an important aspect of pharmacology and medicine. For example, the rate of metabolism determines the duration and intensity of a drug's pharmacologic action. Drug metabolism also affects multidrug resistance in infectious diseases and in chemotherapy for cancer, and the actions of some drugs as substrates or inhibitors of enzymes involved in xenobiotic metabolism are a common reason for hazardous drug interactions. These pathways are also important in environmental science, with the xenobiotic metabolism of microorganisms determining whether a pollutant will be broken down during bioremediation, or persist in the environment. The enzymes of xenobiotic metabolism, particularly the glutathione S-transferases are also important in agriculture, since they may produce resistance to pesticides and herbicides. Drug metabolism is divided into three phases. In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes such as glutathione S-transferases. Finally, in phase III, the conjugated xenobiotics may be further processed, before being recognised by efflux transporters and pumped out of cells. Drug metabolism often converts lipophilic compounds into hydrophilic products that are more readily excreted. (Source: Wikipedia, the free encyclopedia, see http://en.wikipedia.org/wiki/Drug_metabolism)

Note: The extraction of the abstract from the Wikipedia page may sometimes yield imperfect results. We are improving the algorithm regularly.

is rdfs:domain of gr:category gr:color gr:condition gr:depth gr:hasEAN_UCC-13 gr:hasGTIN-14 gr:hasMPN gr:hasManufacturer gr:hasStockKeepingUnit gr:height gr:isAccessoryOrSparePartFor gr:isConsumableFor gr:isSimilarTo gr:weight gr:width
is rdfs:range of gr:includes gr:isAccessoryOrSparePartFor gr:isConsumableFor gr:isSimilarTo

Note: This is a generic list. Some of the properties may not be applicable to this particular type of object.

Trademark Disclaimer: Since this service returns class descriptions for potentiall any series of characters, it cannot indicate automatically whether a name is a registered trademark or otherwise protected. We assume no liability for the absence of trademark rights and other damages. See the section "License" below for details.

[back to top]

Usage

The following shows how to model that you offer to sell [a/an/some] Drug metabolism for $ 19.99.

[back to top]

Microdata / Use with http://schema.org/Product

One of the most powerful usages of the class definitions from this site is to describe the type of your page and product for the schema.org product markup in Microdata syntax much more precisely.

Simply add the full URI of a class from this site, e.g. http://www.productontology.org/id/Drug_metabolism as an additional type as follows:

<div itemscope itemtype="http://schema.org/Product">
    <link itemprop="additionalType" href="http://www.productontology.org/id/Drug_metabolism" />
    <!-- other schema.org properties go in here -->
</div>

Note: In HTML5, it is valid to use the <link> element in the body of a HTML document.

Here is a complete example:

<!DOCTYPE html>
<html>
<head>
    <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
    <title>An offer to sell a / some Drug_metabolism</title>
</head>
<body>
<div itemscope itemtype="http://schema.org/Product" itemid="#product">
    <link itemprop="additionalType" href="http://www.productontology.org/id/Drug_metabolism" />
    <span itemprop="name">.. a short name for the object ...</span>
    Product description: 
    <span itemprop="description">... a longer description ...</span>
    <div itemprop="offers" itemscope itemtype="http://schema.org/Offer" itemid="#offer">
        <span itemprop="price">$19.99</span> 
        <link itemprop="availability" href="http://schema.org/InStock" />In stock
    </div>
</div>
</body>
</html>

Turtle Syntax

@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix pto: <http://www.productontology.org/id/> .
@prefix gr: <http://purl.org/goodrelations/v1#> .
@prefix foo: <http://example.com/> .

# The object
foo:myObject a <http://www.productontology.org/id/Drug_metabolism> ;
	a gr:SomeItems ;
	gr:name "... a short name for the object ..."@en ;
	gr:description "... a longer description ..."@en .

# The agent (person or company) who is offering it
foo:ACMECorp a gr:BusinessEntity ;
	gr:legalName "ACME Corp" ;
	gr:offers foo:Offer .
		
# The offer to sell it
foo:Offer a gr:Offering ;
	gr:includes foo:myObject;
	foaf:page <http://URI_of_the_page_containing_the_offer.com>;
	gr:hasBusinessFunction gr:Sell ;
	gr:validFrom "2011-01-24T00:00:00+01:00"^^xsd:dateTime ;
	gr:validThrough "2011-12-24T00:00:00+01:00"^^xsd:dateTime ;
	gr:hasPriceSpecification
         [ a gr:UnitPriceSpecification ;
           gr:hasCurrency "USD"^^xsd:string ;
           gr:hasCurrencyValue "19.99"^^xsd:float ;
           gr:validThrough "2011-12-24T00:00:00+01:00"^^xsd:dateTime ] .

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

[back to top]

RDFa

<!DOCTYPE html>
<html version="HTML+RDFa 1.1" xmlns="http://www.w3.org/1999/xhtml">
<head>
    <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
    <title>An offer to sell a / some Drug_metabolism</title>
</head>
<body>
<div xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:gr="http://purl.org/goodrelations/v1#"
     xmlns:pto="http://www.productontology.org/id/"
     xmlns:foo="http://example.com/"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#">

<!-- The agent (person or company) who is offering it -->
   <div about="#ACMECorp" typeof="gr:BusinessEntity">
      <div property="gr:legalName">ACME Corp</div>
      <div rel="gr:offers">
<!-- The offer to sell it -->	
         <div about="#offer" typeof="gr:Offering">
            <div rel="gr:hasBusinessFunction" resource="http://purl.org/goodrelations/v1#Sell"></div>
            <div rel="gr:includes">
<!-- The object -->	
               <div about="#myObject" typeof="http://www.productontology.org/id/Drug_metabolism">
                  <div rel="rdf:type" resource="http://purl.org/goodrelations/v1#SomeItems"></div>
                  <div property="gr:description" xml:lang="en">... a longer description ...</div>
                  <div property="gr:name" xml:lang="en">.. a short name for the object ...</div>
               </div>
            </div>
            <div rel="foaf:page" resource="http://URI_of_the_page_containing_the_offer"></div>
            <div rel="gr:hasPriceSpecification">
               <div typeof="gr:UnitPriceSpecification">
                  <div property="gr:hasCurrency" content="USD" datatype="xsd:string">$ </div>
                  <div property="gr:hasCurrencyValue" datatype="xsd:float">19.99</div>
                  <div property="gr:validThrough" content="2011-12-24T00:00:00+01:00" 
					   datatype="xsd:dateTime"></div>
               </div>
            </div>
            <div property="gr:validFrom" content="2011-01-24T00:00:00+01:00"
                 datatype="xsd:dateTime"></div>
            <div property="gr:validThrough" content="2011-12-24T00:00:00+01:00"
                 datatype="xsd:dateTime"></div>
         </div>
      </div>
   </div>
</div>
</body>
</html>

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

[back to top]

RDF/XML

<?xml version="1.0" encoding="UTF-8" ?>
<rdf:RDF xmlns:gr="http://purl.org/goodrelations/v1#" 
  xmlns:pto="http://www.productontology.org/id/" 
  xmlns:xsd="http://www.w3.org/2001/XMLSchema#" 
  xmlns:foaf="http://xmlns.com/foaf/0.1/" 
  xmlns:foo="http://example.com/" 
  xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<!-- The object -->
  <rdf:Description rdf:about="http://example.com/myObject">
    <rdf:type rdf:resource="http://www.productontology.org/id/Drug_metabolism"/>    
    <rdf:type rdf:resource="http://purl.org/goodrelations/v1#SomeItems"/>
    <gr:name xml:lang="en">... a short name for the object ...</gr:name>
    <gr:description xml:lang="en">... a longer description ...</gr:description>
  </rdf:Description>
<!-- The agent (person or company) who is offering it -->
  <gr:BusinessEntity rdf:about="http://example.com/ACMECorp">
    <gr:legalName>ACME Corp</gr:legalName>
    <gr:offers rdf:resource="http://example.com/Offer" />
  </gr:BusinessEntity>
<!-- The offer to sell it -->   
  <gr:Offering rdf:about="http://example.com/Offer">
    <gr:includes rdf:resource="http://example.com/myObject" />
    <foaf:page rdf:resource="http://URI_of_the_page_containing_the_offer"/>
    <gr:hasBusinessFunction rdf:resource="http://purl.org/goodrelations/v1#Sell"/>
    <gr:validFrom rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
      2011-01-24T00:00:00+01:00</gr:validFrom>
    <gr:validThrough rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
      2011-12-24T00:00:00+01:00</gr:validThrough>
    <gr:hasPriceSpecification>
      <gr:UnitPriceSpecification>
        <gr:hasCurrency rdf:datatype="http://www.w3.org/2001/XMLSchema#string">USD</gr:hasCurrency>
        <gr:hasCurrencyValue rdf:datatype="http://www.w3.org/2001/XMLSchema#float">19.99</gr:hasCurrencyValue>
        <gr:validThrough rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">
          2011-12-24T00:00:00+01:00</gr:validThrough>
      </gr:UnitPriceSpecification>
    </gr:hasPriceSpecification>
  </gr:Offering>

</rdf:RDF>

Note: Replace gr:SomeItems (http://purl.org/goodrelations/v1#SomeItems) by gr:Individual if you are describing a unique object of that kind (e.g. antique furniture).

[back to top]

SPARQL Query

prefix foaf: <http://xmlns.com/foaf/0.1/> 
prefix xsd: <http://www.w3.org/2001/XMLSchema#> 
prefix pto: <http://www.productontology.org/id/> 
prefix gr: <http://purl.org/goodrelations/v1#> 
prefix foo: <http://example.com/> 

# Find the cheapest offer for a Drug_metabolism

SELECT * WHERE{
?company gr:offers ?offer .
?offer a gr:Offering .
?offer gr:hasBusinessFunction gr:Sell .
OPTIONAL {?offer rdfs:label ?label } .
OPTIONAL {?offer gr:name ?label } .
OPTIONAL {?offer rdfs:comment ?label } .
OPTIONAL {?offer gr:description ?label } .
?offer gr:hasPriceSpecification ?p .
?p a gr:UnitPriceSpecification .
?p gr:hasCurrency ?currency .
?p gr:hasCurrencyValue ?price .
?offer gr:includes ?product .
?product a <http://www.productontology.org/id/Drug_metabolism> .
}
ORDER BY (?price)
LIMIT 10

[back to top]

Facebook Open Graph Protocol

You can also use the class definitions from this site for better describing the type of your page or product for the Facebook Open Graph Protocol.

Simply define the namespace prefix pto: in the <html> element of your page

<html version="HTML+RDFa 1.1" 
	xmlns="http://www.w3.org/1999/xhtml" 
	xmlns:pto="http://www.productontology.org/id/" 
	>

and use the compact URI (CURIE) pto:Drug_metabolism in combination with og:type as follows:

	<meta property="og:type" content="pto:Drug_metabolism"/>

A complete example is here.

[back to top]

Contact Information

Univ.-Prof. Dr. Martin Hepp

E-Business and Web Science Research Group
Chair of General Management and E-Business
Universität der Bundeswehr München
Werner-Heisenberg-Weg 39
D-85579 Neubiberg, Germany

Phone: +49 89 6004-4217
eMail: mhepp(at)computer.org (preferred mode of communication)
Web: http://www.heppnetz.de/
Web: http://www.unibw.de/ebusiness/

[back to top]

Caching Policy

In order to minimize the load on the Wikipedia API, all requests are cached internally for 72 hours. This means that changes to the English Wikipedia will be available in this service within 72 hours or less if the same entry has been requested before. Classes not requested within the last six hours are always guaranteed to be in sync with the latest version in Wikipedia.

The RDF/XML dump file is updated every 12 hours only.

[back to top]

License

The class definition text is taken from Wikipedia, the free encyclopedia under a Creative Commons Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0) license. Accordingly, the ontology class definitions are available under the very same license.

Trademark Disclaimer: Since this service returns class descriptions for potentially any series of characters, it cannot indicate automatically whether a name is a registered trademark or otherwise protected. If you want us to block a certain name, please send your request including proof of your rights on the name to our contact address listed below.. Any of the trademarks, service marks, collective marks, design rights or similar rights that are mentioned, used, or cited in this service are the property of their respective owners. Their use here does not imply that you may use them for any purpose other than for the same or a similar informational use as contemplated by the original authors of the underlying Wikipedia articles under the CC-BY-SA and GFDL licensing schemes. Productontology.org is neither endorsed by nor affiliated with any of the holders of any such rights and as such cannot grant any rights to use any otherwise protected materials. Your use of any such or similar incorporeal property is at your own risk.

The Product Types Ontology: Class Definition for "Drug metabolism"

pto:Drug_metabolism (rdf:type owl:Class)

Usage

Microdata / Use with http://schema.org/Product

Turtle Syntax

RDFa

RDF/XML

SPARQL Query

Facebook Open Graph Protocol

Contact Information

Caching Policy

License

Acknowledgements

References